About πŸ‘₯

Genome Nexus is a comprehensive resource integrating variant annotations from more than a dozen sources relevant to cancer. The annotations can be accessed through a performant application programming interface and an intuitive user interface, supporting various use cases of variant interpretation. It is freely available under an open source license and can be installed in a private cloud or local environment and integrated with local institutional resources.

Genome Nexus is developed at Memorial Sloan Kettering Cancer Center (MSK) and has received several contributions from The Hyve. The Genome Nexus website is hosted by the Center for Molecular Oncology at MSK. The software is available under an open source license via GitHub.

How do I cite Genome Nexus?

When using Genome Nexus, please cite de Bruijn et al., JCO CCI 2022.

Genome Nexus aggregates variant annotation from various sources. See this documentation for all supported annotation sources. Remember to also cite the underlying annotation sources you are using.

Current Funding

Past Funding


Memorial Sloan Kettering Cancer Center, New York, USA

  • Ino de Bruijn

  • Onur Sumer

  • Xiang Li

  • Angelica Ochoa

  • Manda Wilson

  • Robert Sheridan

  • Avery Wang

  • Hongxin Zhang

  • Aaron Lisman

  • Benjamin Gross

  • Nikolaus Schultz

  • Jianjiong Gao

The Hyve, the Netherlands

  • Sander Rodenburg

  • Pieter Lukasse

  • Sjoerd van Hagen


  • Cyriac Kandoth

  • Zachary Heins

  • Sander Tan

  • Ananthan Sadagopan

  • Alice Thum

  • Emily Zhang

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